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P1‐415: ASSOCIATION BETWEEN PHYSICAL ACTIVITY AND CSF FLOW DYNAMICS
Author(s) -
Sakhare Ashwin,
Isenberg Lisette,
Pa Judy
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.424
Subject(s) - medicine , dementia , cerebrospinal fluid , gating , pathogenesis , pathology , cardiology , disease , physiology
impairment at low genetic risk for Alzheimer’s (defined as APOE ε4 non-carriers), long-term statin-use was associated with lower tau (p1⁄40.033) and marginally non-significantly associated with lower amyloid (p1⁄40.073), with both analyses significant (p1⁄40.030 and p1⁄40.029) after controlling for mid-life dyslipidemia. Conclusions: In this study, long-term statin use was associated with changes in white matter tract integrity even in the absence of changes in overall WMH. Our findings also suggest that statins may have clinical subpopulation-specific protective effects on amyloid and tau deposition. As an avenue to individualized therapy, additional study is warranted to clarify the likely complex interactions of statins with genetic and acquired comorbid factors.