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P1‐409: TREATMENT‐INDUCED CHANGES IN RESTING BRAIN ACTIVITY IN PRIMARY PROGRESSIVE APHASIA
Author(s) -
Bonakdarpour Borna,
Basu Anisha S.,
Grasso Stephanie M.,
Schnyer David M.,
Henry Maya L.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.418
Subject(s) - voxel , inferior frontal gyrus , aphasia , middle frontal gyrus , supramarginal gyrus , medicine , primary progressive aphasia , audiology , superior temporal gyrus , superior frontal gyrus , psychology , functional magnetic resonance imaging , neuroscience , radiology , frontotemporal dementia , dementia , disease
who underwent neuropsychological test and brain MRI. First, we selected cortical area that showed more atrophy in lvPPA compared to AD and defined that area as region of interest (ROI). Second, we calculated asymmetric index (AI) of ROI in each participant and searched for the optimal cut-off of AI (Mean -4.2038, Standard Error 0.0454) that best discriminates lvPPA from AD by using receiver operating characteristic curve. Third, to find patients with right focal atrophy among AD, we selected patients who had AI value above the counter cut-off for lvPPA (3.3104). Finally we characterized cognitive profile of right focal atrophy (Rt-AD) patients by comparing with lvPPA (Lt-AD) and symmetric-AD. Results:14 patients were selected as Rt-AD. There was no significant difference in age, sex, education, MMSE and CDR between Rt-AD, Lt-AD, and symmetric-AD. Rt-AD group showed significant cortical thinning in right temporo-parietal area compared with symmetric-AD patients (p < 0.05 RFT corrected). Compared to symmetric-AD patients, Rt-AD patients showed poor performance in visuospatial function test (p 1⁄4 0.046) and visual memory test (p 1⁄4 0.045). Compared to Lt-AD patients, Rt-AD patients showed poor performance in visuospatial function test (p 1⁄4 0.082) and visual memory test (p 1⁄4 0.005). Conclusions:Our results suggest that there are patients with right predominant focal atrophy among AD. These AD variants with right focal atrophy show prominent visuospatial dysfunction and visual memory impairment.