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P1‐408: 18F‐FDG AND 18F‐AV45 POSITRON EMISSION TOMOGRAPHY IN ALZHEIMER'S DISEASE
Author(s) -
Qiao Zhen,
Chen Qian,
Zhang Wei,
Wang Guihong,
Zhao Xiaobin,
Wang Kai,
Ai Lin
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.417
Subject(s) - positron emission tomography , medicine , temporal lobe , nuclear medicine , white matter , radiology , magnetic resonance imaging , psychiatry , epilepsy
who underwent neuropsychological test and brain MRI. First, we selected cortical area that showed more atrophy in lvPPA compared to AD and defined that area as region of interest (ROI). Second, we calculated asymmetric index (AI) of ROI in each participant and searched for the optimal cut-off of AI (Mean -4.2038, Standard Error 0.0454) that best discriminates lvPPA from AD by using receiver operating characteristic curve. Third, to find patients with right focal atrophy among AD, we selected patients who had AI value above the counter cut-off for lvPPA (3.3104). Finally we characterized cognitive profile of right focal atrophy (Rt-AD) patients by comparing with lvPPA (Lt-AD) and symmetric-AD. Results:14 patients were selected as Rt-AD. There was no significant difference in age, sex, education, MMSE and CDR between Rt-AD, Lt-AD, and symmetric-AD. Rt-AD group showed significant cortical thinning in right temporo-parietal area compared with symmetric-AD patients (p < 0.05 RFT corrected). Compared to symmetric-AD patients, Rt-AD patients showed poor performance in visuospatial function test (p 1⁄4 0.046) and visual memory test (p 1⁄4 0.045). Compared to Lt-AD patients, Rt-AD patients showed poor performance in visuospatial function test (p 1⁄4 0.082) and visual memory test (p 1⁄4 0.005). Conclusions:Our results suggest that there are patients with right predominant focal atrophy among AD. These AD variants with right focal atrophy show prominent visuospatial dysfunction and visual memory impairment.