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P1‐396: COGNITION AND NEUROFIBRILLARY DEGENERATION IN PATIENTS WITH AMYLOID‐NEGATIVE MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE
Author(s) -
Oh Minyoung,
Oh Jungsu S.S.,
Oh Seung Jun,
Lee Sang Ju,
Roh Jee Hoon,
Seo Sang Won,
Lee Jae-Hong,
Kim Jae Seung
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.404
Subject(s) - standardized uptake value , cognitive impairment , psychology , pathology , neuropsychology , dementia , medicine , alzheimer's disease , cognition , disease , neuroscience , positron emission tomography
similar impairment in memory, visuo-spatial and executive functions, but EOAD showed greater impairment in language functions. Rs-fMRI analysis detected the following FC abnormalities: LOAD exhibited decreased FC within the default mode and the limbic networks, while EOAD showed decreased FC in the executive and visual networks. Increased FC was found only in LOAD within the sensorimotor network. Conclusions:Our findings suggest a different pattern of functional network disruption in LOAD and EOAD. Impaired default mode and limbic networks connectivity was specific to LOAD, while networks underlying neocortical and atypical (i.e., visual) functions were affected in EOAD. These findings are in line with the hypothesis that the pathophysiological mechanisms underlying EOAD and LOAD are distinct.