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P1‐381: NEUROIMAGING CHARACTERISTIC OF FRAILTY STATUS IN PATIENTS WITH ALZHEIMER'S DISEASE
Author(s) -
Hirose Daisuke,
Shimizu Soichiro,
Ogawa Yusuke,
Kaneko Yoshitsugu,
Takenoshita Naoto,
Sakurai Hirofumi,
Hanyu Haruo
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.389
Subject(s) - hyperintensity , medicine , atrophy , cardiology , neuroimaging , pathological , ischemia , white matter , disease , temporal lobe , infarction , magnetic resonance imaging , radiology , psychiatry , myocardial infarction , epilepsy
were processed using Freesurfer 6.0, producing volumetric and cortical thickness values. Images were spatially transformed to a template, producing modulated gray segments. Regional volumes were corrected for intracranial volume; all values were ageadjusted. Using discrete values as inputs, and separately, modulated gray segments, canonical variates analysis was applied within an iterative resampling software framework to identify volumetric patterns differentiating conditions, optimized for reproducibility and prediction, and tested using Leave-One-Out and independent subjects. Results:A pattern of atrophy in thalamus, striatum, hippocampus, and inferior temporal gyrus was increasingly expressed in unimpaired and impaired boxers relative to NLs (Figures 1, 2). Expression increased with fight exposure and with age (Figure 3), and boxing vs. MMA. Impaired fighters were differentiated from AD-related MCI and dementia by atrophy in regions including midbrain, thalamus, striatum, and inferior temporal cortex in fighters relative to inferior parietal, fusiform, and entorhinal regions in AD-related subjects, with shared ventricular expansion and hippocampal reduction (Figure 4). Discrete value and voxel-based results were consistent. Conclusions: Machine learning with volumetric MRI provides quantitative biomarkers that characterize the presymptomatic and symptomatic effects of repetitive head trauma related to exposure, time, and impairment, and differentiate effects of mTBI versus AD-related pathology.