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P1‐362: COMPARING A GERMAN VERSION OF THE FIVE WORD TEST WITH THE MINI MENTAL STATE EXAMINATION IN ITS ABILITY TO DISCRIMINATE HEALTHY CONTROLS FROM PATIENTS WITH AMNESTIC MILD COGNITIVE IMPAIRMENT AND EARLY STAGES OF ALZHEIMER'S DISEASE
Author(s) -
Hausner Lucrezia,
Dinu-Biringer Ramona,
Frölich Lutz
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.370
Subject(s) - cognitive impairment , recall , medicine , test (biology) , mini–mental state examination , receiver operating characteristic , audiology , diagnostic accuracy , psychology , disease , paleontology , cognitive psychology , biology
has been incorporated into the Alzheimer’s Disease Neuroimaging Initiative 3, or ADNI 3 (data collection and sharing funded by ADNINational Institutes of Health Grant U01 AG024904), in order to assess the test’s capabilities on a multi-site level. Methods:Baseline clinical FCI-SF scores from 32 sites across the United States were summarized fromADNI 3 as of September 20, 2017. ANOVA comparisons for overall and sub-section scores were performed for normal controls (NC) (n1⁄4111), MCI patients (n1⁄461), and mild Alzheimer’s dementia (mAD) patients (n1⁄411). Multiple comparisons analysis was performed at the item level to identify questions that separated the clinical sub-groups with the greatest significance. Results: A significant separation in overall FCI-SF score (mean 6 SE) was noted between NC (68.0 6 0.51), MCI patients (58.8 6 1.84) and mAD patients (39.5 6 6.46). Clinical subpopulations were also significantly separated based on scores from each of the FCI-SF’s five sub-sections, which include Mental Calculation, Financial Conceptual Knowledge, Single Checkbook/ Register Task, Complex Checkbook/Register Task, and Bank Statement Management. Multiple comparisons analysis revealed that a subset of key items from Single and Complex Checkbook and Bank Statement Management subsections allowed for greatest separation of clinical subpopulations, particularly between NC and MCI. Conclusions:These data confirm that financial abilities decline in the earliest symptomatic stages of AD in a multiple-site setting. In addition to memory, early AD subjects develop deficits associated with a variety of complex tasks, highlighting functional deficits as an early feature of the disease.