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P1‐358: GRN GENOTYPE DISTRIBUTION IN DEMENTIA CLINICAL SYNDROMES AND ITS CORRELATION WITH COGNITIVE FUNCTION
Author(s) -
Liu Caiyan,
Dong Liling,
Mao Chenhui,
Gao Jing
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.366
Subject(s) - dementia , neuropsychology , genotype , cognition , medicine , oncology , montreal cognitive assessment , correlation , psychology , disease , clinical psychology , psychiatry , biology , genetics , gene , geometry , mathematics
Slow walking speed (sWS) was defined as walking with a speed below 0.8 m/s. Hazard ratios (HR) of dementia (according to the DSM-IV edition), with 95% confidence intervals (CI), were estimated using Cox regression analyses. Mixed-effect linear regression models were used to quantify the association between isolated CIND, isolated sWS and the combination of these conditions and cognitive decline (as assessed with the Mini Mental State Examination). Results: During the 9-year follow-up, participants with both CIND and sWS had four times higher risk of dementia (HR: 4.1; 95% CI: 2.9-5.7), as compared with those free from these conditions. When considering isolated CIND or isolated sWS we obtained attenuated results (HR: 2.6; 95% CI: 1.9-3.5; HR: 1.8; 95% CI: 1.2-2.5, respectively). Participants with both CIND and sWS had the worst cognitive performance at baseline (b -1.2 [95%CI -1.4, -1.0], p-value<.001), and the steepest cognitive decline over the follow-up period (b -0.85 [95%CI -0.99, -0.71], p-value<.001), respect to people free from these conditions. Conclusions:The simultaneous presence of CIND and sWS identify a peculiar frail population with a higher risk of dementia and cognitive decline, which might deserve ad hoc assessments and care.