P1‐340: FRONTOTEMPORAL DEMENTIA‐LIKE PHENOTYPE IN SEVEN HISPANIC PATIENTS WITH PRESENILIN‐2

by gender and presence of Lewy bodies (LB). Results:Overall, carriers of ε4 showed a greater frequency of N+ than non-carriers (p1⁄40.017). NAD female carriers had significantly more N+, independent of the presence of LB (p1⁄40.009) (Fig 1). In HAD subjects, homozygous carriers of the ε4 allele showed a significant increase in the frequency of N+ over heterozygous or non-carriers of the ε4 allele; this significant association was present only in females, and only in thosewith LB (p1⁄40.020) (Fig 2). No significant relationship was detected in the IAD group. Conclusions:The effect of ApoE ε4 on N+ seems female predominant, and varies based on AD pathology severity. ApoE ε4 exerts a recessive-like effect on N+ in HAD females, but only in the presence of LB; this finding is similar to the recently reported effect of ε4 on psychosis (1), another common symptom of AD. Our unexpected finding that female NAD ε4 carriers show a higher prevalence of N+, an effect independent of AD pathology and LB, suggests for the possible influence of ApoE ε4 on non-AD related issues not previously recognized. Kim J, Fischer CE, Schweizer TA, Munoz DG. Gender and Pathology-Specific Effect of Apolipoprotein E Genotype on Psychosis in Alzheimer’s Disease. Curr Alzheimer Res. 2017;14(8):834-40.