Premium
F5‐05‐03: THE BDNF VAL66MET SNP IS RELATED TO HIPPOCAMPAL CONNECTIVITY AND COGNITIVE DECLINE IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
Author(s) -
Franzmeier Nicolai,
Ren Jinyi,
Bateman Randall J.,
Morris John C.,
Levin Johannes,
Jucker Mathias,
Benzinger Tammie L.S.,
Ewers Michael,
Yakushev Igor
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2986
Subject(s) - hippocampus , hippocampal formation , neuroscience , episodic memory , psychology , neurotrophic factors , alzheimer's disease , cognitive decline , resting state fmri , cognition , medicine , dementia , disease , receptor
p1⁄4.02-.03 respectively, Fig.2A). Furthermore, higher scores on this personality/NPF component were associated with worse immediate memory (F1,701⁄44.1, p1⁄4.05, Fig.2B), regardless of Ab status. Conclusions: Our multivariate approach revealed that Ab burden was increased in cognitively normal individuals at risk of AD showing high levels of perseverative thinking, neuroticism and apathy, which were in turn related to altered brain connectivity and lower cognition. Overall, these results highlight the importance of personality/NPF burden on early AD pathophysiology.