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O4‐09‐06: MRI, FDG, AND EARLY FRAME AMYLOID IMAGE CLASSIFIERS TO CHARACTERIZE AND DIFFERENTIATE ALZHEIMER'S DISEASE VARIANTS AND NON‐AD DEMENTIAS
Author(s) -
Lukic Ana S.,
Andrews Randolph D.,
Bourakova Viktoriya,
Rabinovici Gil D.,
Matthews Dawn C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2962
Subject(s) - primary progressive aphasia , progressive supranuclear palsy , corticobasal degeneration , medicine , posterior cortical atrophy , dementia , frontotemporal dementia , pathology , neuroscience , atrophy , disease , psychology
Neurobiological and demographical characteristics of cohort. Low CSF b-Amyloid (n 1⁄4 16) High CSF b-Amyloid (n 1⁄4 17) p-value Age at Onset, in years Mean (SD) 57.73 (5.24) 57.05 (5.99) 0.731 Gender, male N(%) 6 (37.5) 10 (58.8) 0.221 Education, in years Mean (SD) 11.00 (4.06) 12.80 (6.04) 0.358 CSF Biomarker Amyloid Count Mean (SD) 365.25 (82.21) 952.37 (376.65) <0.001* pTAU Count Mean (SD) 103.04 (58.59) 49.96 (28.80) <0.001* hTAU Count Mean (SD) 724.29 (365.55) 358.17(228.73) 0.002* Duits, AD positive N(%) 16 (100.0) 4 (23.5) <0.001* Neuroimaging Total MTA Rating (range 0-8) Mean (SD) 3.94 (0.57) 3.76 (0.44) 0.367 Total Fazekas Rating (range 0-12) Mean (SD) 4.19(2.93) 6.50 (3.37) 0.047* ConfluentWMH (>2 any one side; PVH or DSC) N (94) 2(12.5) 7(43.8) 0.049