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FTS4‐01‐02: SUBJECTIVE AND VERY FIRST OBJECTIVE COGNITIVE DECLINE
Author(s) -
Jessen Frank
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2902
Subject(s) - cognitive decline , stage (stratigraphy) , operationalization , cognition , asymptomatic , disease , dementia , psychology , presentation (obstetrics) , medicine , pathology , psychiatry , surgery , paleontology , philosophy , epistemology , biology
reduced and plaque-associated microglia were more numerous in SUS-treated mice. We identified that 14 weekly SUS treatments of K3 mice significantly reduced tau pathology and improved memory and motor functions. We further identified the best of four antibody formats in SUS-mediated uptake across the BBB and into pR5 neurons. Conclusions:Our study suggests therapeutic ultrasound as a viable modality to treat proteinopathies.