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F4‐08‐04: SUBJECTIVE COGNITIVE DECLINE, AS MEASURED WITH A STRUCTURED INTERVIEW, IS RELATED TO AMYLOID PATHOLOGY IN COGNITIVELY HEALTHY OLDER ADULTS
Author(s) -
Miebach Lisa,
Wolfsgruber Steffen,
Frommann Ingo,
Roeske Sandra,
Oliver Peters,
Buerger Katharina,
Nestor Peter,
Ewers Michael,
Laske Christoph,
Priller Josef,
Schneider Anja,
Spottke Annika,
Heneka Michael,
Teipel Stefan J.,
Wiltfang Jens,
Düzel Emrah,
Jessen Frank,
Wagner Michael
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2895
Subject(s) - cognitive decline , logistic regression , dementia , medicine , cognition , disease , explained variation , analysis of variance , clinical psychology , audiology , oncology , psychology , psychiatry , machine learning , computer science
attention/psychomotor speed (r1⁄4-.234, p<.05), and MMSE (r1⁄4.291, p<.05). However, this was found neither within the MCI nor SCD subgroups. There was a negative correlation between NRGR/BC1 and relative amygdala (r1⁄4-.845, p<.001) and hippocampal (r1⁄4-.600, p<.05) volume in the MCI group only. Conclusions: NRGN/BACE1 was similarly increased in the SCD and MCI groups, associated with lower cognitive performance as well as reduced amygdala and hippocampal volumes at baseline. The present results warrant further evaluation of the NRGN/BACE1 ratio as a biomarker for clinical progression in subjects at-risk for dementia due to AD.