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F4‐08‐03: INCREASED CSF NEUROGRANIN/BACE1 RATIO IN AMYLOID POSITIVE SUBJECTS WITH SUBJECTIVE COGNITIVE DECLINE
Author(s) -
Kirsebom Bjørn-Eivind,
Nordengen Kaja,
Selnes Per,
Waterloo Knut,
Brix Britta,
Vanmechelen Eugeen,
Hessen Erik,
Fladby Tormod
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2894
Subject(s) - neurogranin , verbal fluency test , psychology , temporal lobe , medicine , cognition , cognitive decline , audiology , hippocampus , neuroscience , neuropsychology , dementia , disease , biology , biochemistry , protein kinase c , epilepsy , enzyme
Background: Subjective cognitive decline (SCD) has been associated with greater b-amyloid (Ab) burden in clinically normal older adults. Vascular risk factors, such as hypertension, high cholesterol, and diabetes, are common in older adults and increase the likelihood of cognitive decline beyond that of Ab. However, it remains unclear whether vascular risk independently contributes to greater endorsement of SCD, particularly in the setting of high Ab burden. The objective of the present study was to examinewhether vascular risk and Ab burden are independently or interactively associated with SCD in clinically normal older adults. Methods:The sample consisted of 252 clinically normal older adults (mean age 1⁄4 73.9 6 6.1 years) from the Harvard Aging Brain Study. Participants underwent Ab positron emission tomography imaging (C Pittsburgh Compound B). An Ab cortical summary measure was used as a continuous variable in all analyses. Vascular risk was quantified using the office-based Framingham Heart Study cardiovascular disease risk score (FHS-CVD). An SCD composite was created using z-transformed subscales from the Memory Functioning Questionnaire, the Everyday Cognition Memory scale, and a seven-item questionnaire. Ab burden and FHS-CVD were examined as independent and interactive predictors of SCD in separate cross-sectional linear regression models, controlling for age, sex, and education. Secondary analyses additionally controlled for depressive symptoms using the Geriatric Depression Scale (GDS), given known associations with SCD. We used one-tailed significance values due to a priori predictions that increased Ab burden and FHS-CVD would be associated with greater SCD. Results: In a multiple regression model, both higher Ab burden and FHS-CVD were independently associated with greater SCD (Ab: p < 0.001; FHS-CVD: p 1⁄4 0.01). In a separate model, we tested for an interaction between Ab burden and FHS-CVD; the interaction was not significant (p 1⁄4 0.36). When GDS was added as a covariate, Ab burden and FHS-CVD remained significant independent predictors of SCD (Ab: p < 0.001; FHS-CVD: p 1⁄4 0.048; GDS: p< 0.001). Conclusions:Higher Ab burden and higher vascular risk independently contributed to greater endorsement of SCD, even after controlling for depressive symptoms. Assessment of vascular risk is an important component to understanding SCD.