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F4‐07‐02: TAU‐INDUCED PATHOLOGICAL CHANGES IN THE HUMAN LOCUS COERULEUS DURING ALZHEIMER'S DISEASE PROGRESSION
Author(s) -
Theofilas Panos,
Ehrenberg Alexander J.,
Heinsen Helmut,
Grinberg Lea Tenenholz
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2889
Subject(s) - tauopathy , locus coeruleus , brainstem , neurodegeneration , biology , programmed cell death , tau protein , pathological , neuroscience , pathology , alzheimer's disease , microbiology and biotechnology , disease , apoptosis , medicine , central nervous system , biochemistry
is modulating frontoparietal network activity and thereby influencing selective attention.We find age-related impairments in these processes that can be alleviated by increasing tonic LC activity with a simple exercise. In addition, diminished connectivity between the LC and frontoparietal network is associated with decreased LC neuromelaninMRI contrast. Thus, our findings not only provide evidence of age-related decline in LC function, but also provide insights into how exercise can enhance cognition in aging.