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F4‐03‐02: INCREASED ATROPHY IN THE DEFAULT MODE NETWORK IS ASSOCIATED WITH DEVELOPMENT OF DELUSIONS IN ALZHEIMER'S DISEASE
Author(s) -
Qian Winnie,
Millikin Colleen,
Ismail Zahinoor,
Smith Eric E.,
Munoz David G.,
Schweizer Tom A.,
Fischer Corinne E.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2873
Subject(s) - precuneus , posterior cingulate , default mode network , psychology , delusion , atrophy , alzheimer's disease , lingual gyrus , audiology , cognition , neuroimaging , superior frontal gyrus , delusional disorder , middle frontal gyrus , neuroscience , disease , psychiatry , medicine , psychosis
left inferior parietal lobule with the rest of the network compared to the non-delusional group. Conclusions:Delusions in AD appear to be associated with disruption in connectivity within the DMN, particularly the left inferior parietal lobulewith the overall network. The DMN and inferior parietal lobules are involved in many higher order cognitive functions, including self-monitoring, mind-wandering, concept of self, Theory of Mind, empathy, and imagining the future. Conceivably, breakdown in these cognitive functions via altered network communication may contribute to poor insight and impaired social cognition that can lead to development of delusions.