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O3‐13‐04: [18F]‐AV‐1451 BINDING PROFILE IN EARLY AND LATE‐ONSET ALZHEIMER'S DISEASE AND SUSPECTED NON‐ALZHEIMER PATHOPHYSIOLOGY
Author(s) -
Stage Eddie,
Svaldi Diana Otero,
Phillips Meredith,
Risacher Shan L.,
Duran Tugce,
Saykin Andrew J.,
Apostolova Liana G.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2846
Subject(s) - pittsburgh compound b , neuropathology , voxel , alzheimer's disease , early onset alzheimer's disease , pathophysiology , medicine , snap , dementia , pathology , cardiology , nuclear medicine , psychology , disease , radiology , computer graphics (images) , computer science
between tau and the other three biomarkers. For the entire sample there was a significant correlation between precuneus tau and PiB (r1⁄40.73, p1⁄40.4), FDG (r1⁄4-0.63, p1⁄40.002), and cortical thickness (r1⁄4-0.69, p1⁄40.3). The strength of these relationships varied by group (Figure 5) but were particularly prominent in the sMCs. Conclusions:We found overlapping spatial patterns of biomarker change in ADAD, with pathological changes consistently located in the precuneus and lateral parietal regions across all four biomarkers. The degree of beta-amyloid, hypometabolism, and cortical thinning were all strongly correlated with tau pathology measured with flortaucipir. O3-13-04 [18F]-AV-1451 BINDINGPROFILE IN EARLY AND LATE-ONSETALZHEIMER’S DISEASE AND SUSPECTED NONALZHEIMER PATHOPHYSIOLOGY