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O3‐13‐01: PATTERNS OF GLUCOSE HYPOMETABOLISM, SUBCORTICAL ATROPHY AND WHITE MATTER HYPERINTENSITIES IN THE BEHAVIORAL VARIANT OF ALZHEIMER'S DISEASE
Author(s) -
Singleton Ellen H.,
Pijnenburg Yolande A.L.,
Sudre Carole H.,
Kochova Elena,
Groot Colin,
Papma Janne M.,
Ourselin Sebastien,
Swieten John C.,
Barkhof Frederik,
Cardoso M. Jorge,
Scheltens Philip,
Rabinovici Gil D.,
Ossenkoppele Rik
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2843
Subject(s) - precuneus , globus pallidus , psychology , hyperintensity , insula , posterior cingulate , neuroscience , white matter , atrophy , ventral pallidum , temporal lobe , frontal lobe , pathology , medicine , basal ganglia , magnetic resonance imaging , central nervous system , radiology , cognition , epilepsy
an independent predictor of episodic memory only. Post-hoc analyses showed a significant effect of CR in the high-BR group only. The inclusion of the interactive effect as correction factor in the study of voxel-by-voxel anatomical correlates of episodic memory led to a larger mediotemporal cluster, but not for semantic memory. Conclusions: The statistical relevance of the interactive effect indicates that CR contributes to enrich the pattern of neural resources at disposal of memory processing, building on BR. This, does not benefit all types of memory, but is significantly relevant only for episodic memory. Differently from semantic memory that is sustained by a wide pattern of regions, episodic memory is more distinctively sustained by the function of the hippocampus, a structure particularly susceptible to the impact of physiological and pathological ageing. It is argued that, when levels of BR are high, it is possible to induce the rearrangement of hippocampal connections via engagement in activities boosting CR. When BR is not high, on the other hand, CR would help sustain episodic memory to a normal extent.