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O3‐12‐01: DECREASED META‐MEMORY FOR EPISODIC BUT NOT SEMANTIC INFORMATION IS ASSOCIATED WITH EARLY TAUOPATHY IN CLINICALLY NORMAL OLDER ADULTS
Author(s) -
Vannini Patrizia,
Uquillas Federico d'Oleire,
Jacobs Heidi,
Sepulcre Jorge,
Gatchel Jennifer R.,
Amariglio Rebecca,
Hanseeuw Bernard J.,
Hedden Trey,
Rentz Dorene M.,
Pascual-Leone Alvaro,
Papp Kathryn V.,
Johnson Keith A.,
Sperling Reisa A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2837
Subject(s) - episodic memory , semantic memory , psychology , semantic dementia , dementia , cognitive psychology , cognition , disease , medicine , neuroscience , frontotemporal dementia
used to examine the association of T2D with brain FDG-PET to incorporate within-pair and between-pair variation. Results:We recruited 23 (12 dizygotic pairs, 11 monozygotic pairs) pairs (mean age 63.7 years (SD 6.1)). The mean duration of T2D was 10.7 years (SD 11) and the mean pre-PET glucose in those with T2D was 7.9 (SD 1.5). None of the participants had dementia. T2D was associated with lower SUVR in whole brain, and lower bilateral frontal, parietal, temporal, occipital and cingulate cortices (all p<0.05). These associations remained even after adjusting for differences in sex and age between twin pairs. Conclusions: T2D was associated with cerebral hypometabolism in regions similar to those seen in AD. T2D may thus have adverse effect on neuronal function long before the development of clinically apparent cognitive decline. Mechanistic pathways involving glucose use and insulin resistance may be responsible for this, and require further study.