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O3‐10‐05: ROBUST MOLECULAR PROPERTIES UNDERLYING REGIONAL VULNERABILITY TO AMYLOID DEPOSITION AND NEURODEGENERATION IN ALZHEIMER'S DISEASE
Author(s) -
Jelistratova Irina,
Sepulcre Jorge,
González-Escamilla Gabriel,
Teipel Stefan J.,
Grothe Michel J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2829
Subject(s) - neurodegeneration , transcriptome , biology , biomarker , gene expression , human brain , neuroimaging , gene , microarray , neuroscience , gene expression profiling , computational biology , genetics , disease , pathology , medicine
Figure 1. Data-driven subtypes of AD as estimated by SuStaln. SuStaln estimates a distinct progression of regional atrophy for each subtype. The colour code refers to the severity of the atrophy at each stage in the progression, measured by the number of standard deviations difference relative to an Ab-negative cognitivelynormal control group. Membership to the two predominant subtypes: Group 1 (typical) or Group 2 (limbic-predominant) was used as a binary trait in the GWAS.