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O3‐10‐02: A PRELIMINARY INVESTIGATION ON THE RELATIONSHIP BETWEEN PREDICTED BRAIN AGE AND GENETICS IN ALZHEIMER'S
Author(s) -
Riedel Brandalyn,
Thompson Paul M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2826
Subject(s) - genome wide association study , neuroimaging , brain size , psychology , twin study , genetic architecture , cognition , population , alzheimer's disease , disease , medicine , neuroscience , biology , genetics , magnetic resonance imaging , quantitative trait locus , heritability , single nucleotide polymorphism , genotype , environmental health , radiology , gene
In EOAD ε4+ and LOAD ε4group, correlation matrix of interregional F-THK5351 retention revealed significant correlation in the more cortical regions (figure 2). Cognitive functions significantly correlated with cortical THK retention except for LOAD ε4-. Cerebrovascular disease markers, such as white matter hyperintensity volume, number of lacunes were greater in the LOAD ε4than LOAD ε4, whereas, those were not significantly different between EOAD ε4+ and EOAD ε-. Scatter plot indicating global FTHK5351 retention in the x axis and global FMM retention in the y axis showed that those in the EOAD ε4+ and LOAD ε4+ were intermingled each other, whereas, EOAD ε4and LOAD ε4were quite different groups (figure 3). Conclusions: In EOAD ε4-, most of which were hippocampal sparing type of AD, tau and amyloid may develop more abruptly and independently. In