P1‐266: LONG‐TERM BLOOD PRESSURE EXPOSURE AND CEREBRAL VASOREACTIVITY: DOES RACE MATTER?

with age. Cognitive decline correlated with age (P < 0.05) but not with the motor severity defined using UPDRS part III scores (P 1⁄4 0.21). Kaplan–Meier survival analyses showed that PD patients carrying the G allele of the rs6269 variant and COMT haplotypes constituting the G allele of rs6269 showed a significantly more rapid decline in the MMSE scores over the follow-up period (logrank test, P < 0.01). Cox proportional regression analysis adjusted for covariates revealed that among patients with PD, those carrying the high-COMT activity haplotype (G_C_C_G for rs6269, rs4633, rs4818, and rs4680) showed a high risk of cognitive decline (hazard ratio 1⁄4 3.24; P 1⁄4 0.02). Conclusions:Our findings suggest that the high-COMTactivity haplotype is associated with cognitive decline in patients with PD. ve DBP. Abbreviations: CI1⁄4 confidence interval; DBP1⁄4 diastolic blood pressure; BP 1⁄4 systolic blood pressure; VR 1⁄4 vasoreactivity. P1-265 BLOOD PRESSURE TRAJECTORIES ARE MOREPREDICTIVEOFNEUROVASCULAR DECOUPLING THAN JUSTA DIAGNOSIS OF HYPERTENSION