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P1‐266: LONG‐TERM BLOOD PRESSURE EXPOSURE AND CEREBRAL VASOREACTIVITY: DOES RACE MATTER?
Author(s) -
Duque Cristina,
Sabayan Behnam,
Garner Chaney R.,
Kurian Shawn,
Velpen Isabelle,
Sedaghat Sanaz,
Jacobs David R.,
Allen Norrina,
Lloyd-Jones Donald,
Sorond Farzaneh
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.272
Subject(s) - medicine , blood pressure , cardiology , transcranial doppler , blood flow , middle cerebral artery , cerebral blood flow , diastole , cohort , ischemia
with age. Cognitive decline correlated with age (P < 0.05) but not with the motor severity defined using UPDRS part III scores (P 1⁄4 0.21). Kaplan–Meier survival analyses showed that PD patients carrying the G allele of the rs6269 variant and COMT haplotypes constituting the G allele of rs6269 showed a significantly more rapid decline in the MMSE scores over the follow-up period (logrank test, P < 0.01). Cox proportional regression analysis adjusted for covariates revealed that among patients with PD, those carrying the high-COMT activity haplotype (G_C_C_G for rs6269, rs4633, rs4818, and rs4680) showed a high risk of cognitive decline (hazard ratio 1⁄4 3.24; P 1⁄4 0.02). Conclusions:Our findings suggest that the high-COMTactivity haplotype is associated with cognitive decline in patients with PD. ve DBP. Abbreviations: CI1⁄4 confidence interval; DBP1⁄4 diastolic blood pressure; BP 1⁄4 systolic blood pressure; VR 1⁄4 vasoreactivity. P1-265 BLOOD PRESSURE TRAJECTORIES ARE MOREPREDICTIVEOFNEUROVASCULAR DECOUPLING THAN JUSTA DIAGNOSIS OF HYPERTENSION