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O2‐11‐02: THE ROLE OF SOLUBLE TNF IN METABOLIC DYSFUNCTION AND BBB ALTERATIONS IN A MOUSE MODEL OF ALZHEIMER'S DISEASE
Author(s) -
Tansey Malu G.,
MacPherson Kathryn P.,
Eidson Lori N.,
Herrick Mary K.,
Elizabeth de Sousa Rodrigues Maria,
Oliver Danielle,
Kelly Sean D.,
Yang Yuan,
Chang Jianjun,
Sniffen Lindsey
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2701
Subject(s) - neuroinflammation , immune system , inflammation , tumor necrosis factor alpha , cytokine , endocrinology , chemokine , proinflammatory cytokine , blood–brain barrier , medicine , immunology , neurodegeneration , biology , central nervous system , disease
between individuals of the same neighborhood. Results:A limited activity space modifies the association between neighborhood socioeconomic status and dementia incidence. In people whose activity space was limited to their neighborhood (n1⁄4772, 11%), living in a deprived neighborhood was associated with a higher risk of dementia (3C deprivation score: T3 HR 1⁄4 1.45, 95% CI 1.01-2.06); conversely living in an advantaged neighborhood was associated with a lower risk (Table 1). These results were not evidenced for peoplewhose activity spacewas not limited.Conclusions:This study shows the role of activity space in health inequalities, in addition to highlighting the importance of the living environment on cognitive ageing. If confirmed in different populations, these findings would help to identify groups at risk, best target for prevention. 1. Letellier N et al. (2017). Sex-specific association between neighborhood characteristics and dementia: The Three-City cohort. Alzheimers Dement.