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P1‐264: CATECHOL‐O‐METHYLTRANSFERASE ( COMT ) GENETIC VARIANTS ARE ASSOCIATED WITH COGNITIVE DECLINE IN PATIENTS WITH PARKINSON'S DISEASE
Author(s) -
Lin Chin-Hsien
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.270
Subject(s) - rs4680 , catechol o methyl transferase , haplotype , cognitive decline , medicine , hazard ratio , dementia , cognition , parkinson's disease , psychology , oncology , cohort , allele , disease , psychiatry , genetics , biology , confidence interval , gene
rated by biomarker of interest and by amyloid and p-Tau positivity, dis played as "AD Pathology Positive" or "AD Pathology Negative." Though linear mixed effects models were performed in the sample as a whole, fo ease of interpretation the blue line represents the top quartile value o each neurodegeneration biomarker (e.g. value above 75% of the sample for NFL), and the red line represents the bottom quartile value (e.g. value below 25% of the sample for NFL). 95% confidence intervals were obtained using parametric bootstrapping in R (bootMer). Akaike information crite rion (AIC) and log likelihood ratio tests indicated that higher neurofilamen light (NFL) protein predicts a steeper rate of decline, whereas no effects on cognitive slope were observed for t-Tau or Neurogranin (NG). Poster Presentations: Sunday, July 22, 2018 P382