Premium
O2‐04‐01: COMPARING BIOMARKER RATES OF CHANGE IN AUTOSOMAL DOMINANT VERSUS SPORADIC ALZHEIMER DISEASE
Author(s) -
Morris John C.,
Weiner Michael,
Beckett Laurel,
Buckles Virginia D.,
Xiong Chengjie
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2657
Subject(s) - psen1 , alzheimer's disease neuroimaging initiative , biomarker , oncology , medicine , early onset alzheimer's disease , alzheimer's disease , amyloid beta , amyloid (mycology) , asymptomatic , neuroimaging , disease , presenilin , pathology , biology , genetics , psychiatry
Age, mean (SD) 91.5 (2.8) 92.2 (2.9) NS Sex (female) 13 (43.3%) 25 (35.7%) NS Education, years, mean (SD) 15.4 (2.9) 14.6 (2.6) NS APOE4 5/28 (17.9%) 10/66 (15.2%) NS APOE2 2/28 (7.1%) 8/66 (12.1%) NS Baseline cognitive measures, mean (SD) Estimated premorbid IQ (AMNART) 121.1 (7.5) 118.0 (7.6) .07 Raven’s Progressive Matrices 31.4 (3.3) 28.2 (4.2) <.001 Trail Making Test part B (seconds) 79.3 (25.0) 97.6 (38.2) .02 California Verbal Learning Test (sum of learning trials) 49.4 (9.5) 40.8 (12.1) .001