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O2‐03‐04: CEREBRAL AMYLOID ANGIOPATHY CORRELATES WITH COGNITIVE DECLINE IN PRECLINICAL AD
Author(s) -
Malek-Ahmadi Michael,
Chen Kewei,
Perez Sylvia E.,
Mufson Elliott J.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2654
Subject(s) - cerebral amyloid angiopathy , neuropathology , cognitive decline , senile plaques , dementia , medicine , cognition , alzheimer's disease , pittsburgh compound b , psychology , pathology , disease , psychiatry
indicated no differences in overall disease progression between EOAD and LOAD (Table 3). Finally, differences in atrophy patterns between subtypes, although subtle, were also appreciable when comparing the memory subtype against each non-amnestic subtype (Figure 3). Conclusions: Cognitively-defined subtypes within the spectrum of typical AD show distinct patterns of atrophy, which are more pronounced in EOAD. There is considerable clinical and neurobiological heterogeneity within the spectrum of ‘typical’ AD.