Premium
P4‐187: AN ALTERNATIVE FATE OF DEGENERATIVE HIPPOCAMPAL NEURONS
Author(s) -
Suo William Z.,
Zhang Qiang,
Singh Prabhakar,
Peng Wei
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2592
Subject(s) - neuroscience , neurodegeneration , hippocampal formation , neurite , degeneration (medical) , neuron , biology , programmed cell death , hippocampus , disease , medicine , pathology , apoptosis , biochemistry , in vitro
freedom spanned by a subset of available markers. Novel biomarkers played a crucial role in achieving this separation. Interestingly, SMC subjects contributed significantly to 4 out of 8 clusters, 2 of which were also dominated by AD. Clinical SMC, MCI, and ADD diagnoses as well as HC therefore appear to lie on a CSF biomarker continuum which does not correspond to unbiased data-driven stratification results. This suggests that the AD pathophysiological dimension is highly complex and not predicted by clinical phenotypes.