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P4‐186: INNOVATIVE BIOMARKER‐GUIDED DIAGNOSTIC SYSTEM FROM PRECLINICAL TO ALZHEIMER'S DISEASE DEMENTIA
Author(s) -
Toschi Nicola,
Lista Simone,
Baldacci Filippo,
Vergallo Andrea,
Zetterberg Henrik,
Blennow Kaj,
Kilimann Ingo,
Teipel Stefan J.,
Cavedo Enrica,
Melo dos Santos Antonio,
Lamari Foudil,
Genthon Remy,
Dubois Bruno,
Floris Roberto,
Garaci Francesco
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2591
Subject(s) - biomarker , memory clinic , dementia , cerebrospinal fluid , medicine , oncology , cohort , neurodegeneration , disease , cognitive impairment , psychology , biology , biochemistry
it is not clear whether this relationship is the same for older people with mental health problems. Mental health problems are also associated with poor cognitive function and difficulties in social relationships. Therefore, we aimed to explore social relationships and cognitive function in older people with mental health problems. Methods: Baseline and two year follow-up data were analysed from the Cognitive Function and Ageing Study–Wales (CFASWales). ANCOVAs were conducted to compare differences in social isolation, loneliness, social contact, cognitive function, and cognitive reserve at baseline amongst older peoplewith and without mental health problems (N 1⁄4 2,135). Linear regression modelling was used to assess the relationship between social isolation and cognition in a subgroup of older people with mental health problems (N1⁄4 186) andmoderation analysis was used to test the moderating effect of cognitive reserve. Results:Older people with mental health problems perceived themselves as more isolated and lonely than those without mental health problems, despite having an equivalent level of social contact with friends and family. In people with mental health problems, social isolation was associated with poor cognitive function at baseline, but not with cognitive change at two year follow-up. Cognitive reserve did not moderate this association. 57% of the people whowere experiencing clinically relevant symptoms of depression or anxiety at baseline were no longer experiencing these symptoms at two year follow-up. Conclusions: Social isolation may be associated with poor cognitive function in people with mental health problems at baseline. The observation that cognitive function does not decrease over two years may be attributed to the improvement in symptoms associated with mental health over the two year follow-up period. This has important implications for interventions aiming to enhancemental health and social contact in later life.