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P4‐177: RELATIONSHIP BETWEEN BODY COMPOSITION AND COGNITIVE FUNCTION: USING BIOELECTRICAL IMPEDANCE ANALYSIS
Author(s) -
Lee Kang Joon,
Jung Han-Yong,
Kim Hyun,
Roh Jihyun
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2582
Subject(s) - bioelectrical impedance analysis , dementia , medicine , fat mass , skeletal muscle , sarcopenia , linear regression , cognition , lean body mass , endocrinology , body weight , cardiology , body mass index , disease , mathematics , psychiatry , statistics
using validated neuropsychological tests. Data extraction and assessment of quality were performed by two independent reviewers and data were summarized using a narrative review. Results: Twelve studies met the inclusion criteria, with a high degree of heterogeneity relating to the nature of the dietary intervention and cognitive outcomes measured, thus making comparisons difficult and precluded pooling of studies formeta-analysis. For methodological quality, n1⁄47 studies were allocated a low to moderate quality score (Jadad et al., 1996).Overall, it was evident that the findings were inconsistent across the studies and do not provide clear evidence to support the effect of diet on cognition in MCIpatients. Supplementationwith eitherVitaminEorGinkgoBiloba, hadno significant effect on progression fromMCI to dementia and/or AD. For cognitive function, there were some improvements in cognitive performance, particularly in the domain of memory, with the most consistent results shown by B vitamin, folic acid and cocoa flavonol supplementation. Furthermore, therewere indications that the use of neuroimaging and biomarker outcomemeasuresmayprovide amore sensitive approach to detect changes in cognitive function and dietary change in comparison to clinical tests.Conclusions:This systematic review highlighted that to date, there is insufficient clinical trial data on the effect of diet on cognitive outcomes in MCI patients. There is need for further well-designed RCTs, with standardised and robust measures of cognition to further explore the role of diet in cognitive decline.