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P4‐114: RACIAL MEASUREMENT INVARIANCE OF THE NATIONAL ALZHEIMER'S COORDINATING CENTERS UNIFORM DATASET NEUROPSYCHOLOGICAL BATTERY
Author(s) -
Avila Justina F.,
Gonzalez Elisa,
Atencio Laura,
Mark Montoya,
Verney Steven P.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2518
Subject(s) - structural equation modeling , psychology , confirmatory factor analysis , measurement invariance , neuropsychology , cognition , neuropsychological test , effects of sleep deprivation on cognitive performance , executive functions , dementia , developmental psychology , clinical psychology , medicine , psychiatry , statistics , disease , mathematics , pathology
Background: Decline in episodic memory is a hallmark clinical feature of Alzheimer’s disease that is evident in early stages of disease. Current models propose that AD begins with accumulation of beta-amyloid (Ab), followed by aggregation of tau, which in turn gives rise to loss of brain volume, impairment in cognition, and ultimately dementia. AD has a lengthy preclinical period, with this accumulation process beginning up to 30 years prior to the onset of dementia. Evidence of elevated Ab levels in both cognitively normal (CN) older adults and individuals with mild cognitive impairment (MCI) indicates that the AD process has begun. This study aimed to characterise the nature and extent of episodic memory decline, associated with Ab in individuals classified as CN and MCI. Methods:Participants (N1⁄4109; 50 AbCN, 25 Ab+ CN, 12 AbMCI, 22 Ab+ MCI) from the Australian Imaging, Biomarkers, and Lifestyle (AIBL) study underwent repeated assessment with a verbal list learning task (International Shopping List Test; ISLT) over 18-months. Results:Compared to AbCNs, Ab+ CNs showed a significant decline in ISLT total score, of a moderate magnitude (Cohen’s d 1⁄4 -0.55[-1.04, -0.07]. AbCNs showed significant improvement on their ISLT total performance over time. Compared to AbCNs, AbMCIs ISLT total and delayed recall scores did not significantly decline over time (Cohen’s d’s 1⁄4 -0.69[-1.33, 0.04] and 0, respectively); however significant decline was evident in Ab+ MCIs on both total and delayed recall (Cohen’s d’s 1⁄4 -1.21 [-1.75, -0.67] and -0.91[-1.44, -0.39], respectively). Conclusions: Significant decline in verbal memory was evident in Ab+ MCIs only, while performance in the AbCNs significantly increased. Further, results indicate that AbMCIs are characteristically different from Ab+ MCIs, and that a lack of decline in episodic memory, particularly delayed verbal recall, in MCI is indicative of a process separate from Alzheimer’s disease. Lastly, results suggest that cognitive abnormality in Ab+ CNs may be conceptualised as a reduced benefit from repeated exposure to stimuli.