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P4‐111: NEUROPSYCHOLOGICAL DECLINE IMPROVES PREDICTION OF DEMENTIA BEYOND BIOMARKERS OR SUBJECTIVE COGNITIVE COMPLAINTS
Author(s) -
Nation Daniel A.,
Ho Jean K.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2515
Subject(s) - neuropsychology , dementia , neuropsychological test , cognitive decline , psychology , verbal fluency test , biomarker , neuropsychological assessment , neuroimaging , clinical psychology , cognition , medicine , audiology , disease , psychiatry , biochemistry , chemistry
Multiple regression analysis was used to test the predictive value of SCCs at baseline, controlling depression, age and years of schooling on general cognitive performance at follow-up. Results: SCCs correlated significantly with depression, general cognitive performance and episodic memory at baseline (Table 2). General cognitive performance at follow-up was predicted by SCCs from informants at baseline jointly with age and years of schooling explaining 46% of the variance (Model 4 in Table 3), but not by depression (Model 2 in Table 3). Conclusions:SCCs are correlated with depression, general cognitive performance and episodic memory at baseline. SCCs from informants but not depression are relevant in the prediction of cognitive performance over time.