Premium
P4‐108: RESTING‐STATE FUNCTIONAL CONNECTIVITY IS ASSOCIATED WITH PATHOLOGICAL BIOMARKERS IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
Author(s) -
Smith Robert X.,
Tanenbaum Aaron,
Strain Jeremy F.,
Gordon Brian A.,
Fagan Anne M.,
Hassenstab Jason,
McDade Eric,
Xiong Chengjie,
Chhatwal Jasmeer P.,
Morris John C.,
Benzinger Tammie L.S.,
Bateman Randall J.,
Ances Beau M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2512
Subject(s) - resting state fmri , correlation , dementia , magnetic resonance imaging , neuroscience , pathological , positron emission tomography , alzheimer's disease , pathology , medicine , disease , psychology , mathematics , radiology , geometry
with nonlinear transformations. The SUVR parametric map was generated using cerebellar grey matter as a reference region for both images. For statistical analysis, we performed voxel-wise analysis to show the association between amyloidosis and NFTs following the model in each group using VoxelStats. [F] MK6240 SUVR w [F]AZD4694 SUVR + age + gender + APOE + education. Results: The unique association between amyloidosis and NFTs was present in entorhinal cortex and PCC in CN; precuneus, PCC, and parahippocampal gyrus in MCI; ACC, entorhinal cortex, parahippocampal gyrus, and orbitofrontal cortex in AD. All groups showed the association in lateral temporal and middle frontal gyrus. Conclusions: Our results revealed both similar and different association patterns between amyloidosis and NFTs across AD stage. Most common association pattern was present at left lateral temporal cortex across all stages while the different association pattern moved from PCC, precuneus, to orbitofrontal cortex in CN, MCI, and AD, respectively. This corroborates the two pathologies spread from the posterior to anterior regions of the brain.