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P4‐103: PARKINSON'S DISEASE: BRAIN METABOLIC CORRELATES OF NIGROSTRIATAL DEGENERATION IN STRIATAL SUBREGIONS DEFINED BY CORTICO‐STRIATAL CONNECTIVITY
Author(s) -
Apostolova Ivayla,
Lange Catharina,
Frings Lars,
Mester Janos,
Klutmann Susanne,
Adam Gerhard,
Meyer Philipp Tobias,
Buchert Ralph
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2507
Subject(s) - putamen , striatum , parkinson's disease , diffusion mri , caudate nucleus , psychology , neuroscience , nuclear medicine , medicine , pathology , magnetic resonance imaging , disease , radiology , dopamine
Background:While near infrared fluorescence (NIRF) imaging has been widely used in preclinical studies, its low tissue penetration represents a daunting problem for translational clinical imaging of neurodegenerative diseases. Retina is known as an extension of the central nerve system (CNS), and it is widely considered as a window to a brain. Therefore, retina can be considered as an alternative organ for investigating neurodegenerative diseases. From an NIRF imaging standpoint, an eye represents an ideal imaging organ, due to its minimal opacity. Methods: In this report, we demonstrated that, for the first time, Near Infrared Fluorescence Ocular Imaging (NIRFOI) could potentially be applied for diagnosis of Alzheimer’s disease. In our previous studies, we described “smart” fluorescent probes for amyloid beta (Ab) (CRANAD-X (X 1⁄4 -2, -3, -30, -58, and -102)) and used them for non-invasive NIRF imaging of Ab species in brains of transgenic AD mice. Here, we demonstrated that these probes also could be used for imaging of Abs in the eyes (Fig.1). Results:Compared to NIRF of brains, NIRFOI has remarkable translational potential for future human studies, as the eye has significantly better transparency for optical imaging. Moreover, our preliminary results demonstrated that NIRFOI could provide much higher sensitivity for imaging Abs than brain NIRF did (Fig.1). This large margin is very important for both diagnosis and therapy response monitoring. Although fluorescence microscopic imaging has been used for detection of Ab plaques in AD mice and human AD patients, but it could not be used to detect soluble Abs, because there is no observable morphology of soluble Abs under fluorescence microscope. However, NIRFOI captures signals with a wide angle (large FOV), and can collect all of the signals from eyes. Therefore we believe that NIRFOI imaging is one of such technologies that can capture the imaging signals from both soluble and insoluble Ab species. Conclusions:In conclusion, we believe that NIRFOI can be a potential imaging technology for fast, cheap, accessible, and reliable diagnosis of AD with a primary-care setting. P4-103 PARKINSON’S DISEASE: BRAIN METABOLIC CORRELATES OF NIGROSTRIATAL DEGENERATION IN STRIATAL SUBREGIONS DEFINED BY CORTICO-STRIATAL CONNECTIVITY Ivayla Apostolova, Catharina Lange, Lars Frings, Janos Mester, Susanne Klutmann, Gerhard Adam, Philipp Tobias Meyer, Ralph Buchert, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Charit e–Universitaetsmedizin Berlin, Berlin, Germany; University Hospital Freiburg, Freiburg, Germany. Contact e-mail: ivaapost@hotmail.com