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P4‐100: ANALOGOUS RELATIONSHIP BETWEEN SERUM TAU AND BRAIN TAU DEPOSITION AMONG PATIENTS WITH COGNITIVE DECLINE
Author(s) -
Yadav Saroj Kumar,
Dey Aparajit Ballav,
Dey Sharmistha
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2503
Subject(s) - posterior cingulate , cognition , cognitive decline , tau protein , dementia , memory clinic , medicine , depression (economics) , biomarker , psychology , neuroscience , oncology , disease , alzheimer's disease , chemistry , biochemistry , macroeconomics , economics
education (HR1⁄41863, LR1⁄41263; p<0.001) and TIV (HR1⁄413766160cc, mLR1⁄414956210cc; p1⁄40.013). No significant between group differences were found in AD MRI proxies and WMH volumes. As to WM integrity, HR compared to mLR displayed widespread increased FA on the entire skeleton, with the highest significance in: genu and splenium of the corpus callosum, anterior corona radiata, fornix and cingulum (cingulate gyrus). Conversely, they displayed reduced FA in the body of corpus callosum, superior corona radiata, posterior limb of internal capsule and right cingulum (hippocampus). Conclusions: HR and mLR differed for established reserve proxies (TIV and education). In contrast to previous findings in AD patients, AD MRI proxies and WMH resulted comparable between groups. The widespread increased WM integrity found in HR compared to mLR suggests a prominent neuroprotective mechanism of CR in SCD. Moreover, the reduced WM integrity found in tracts crossing brain regions early affected by AD pathology, could explain concurrent regionally-specific compensation mechanisms.