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P4‐094: OCCIPITAL TO GLOBAL PIB UPTAKE IS ASSOCIATED WITH THE PRESENCE OF MICROHEMORRHAGES AND MUTATIONS ASSOCIATED WITH CEREBRAL AMYLOID ANGIOPATHY IN THE DOMINANTLY INHERITED ALZHEIMER'S NETWORK
Author(s) -
Joe Elizabeth B.,
Joseph-Mathurin Nelly,
Benzinger Tammie L.S.,
Bateman Randall J.,
McDade Eric,
Ghetti Bernardino Francesco,
Levin Johannes,
Vöglein Jonathan,
Fox Nick C.,
Sperling Reisa A.,
Chhatwal Jasmeer P.,
Noble James,
Salloway Stephen,
Chui Helena C.,
Ringman John M.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2497
Subject(s) - cerebral amyloid angiopathy , dementia , pittsburgh compound b , asymptomatic , medicine , alzheimer's disease , pathology , gastroenterology , disease
contact) and overall social network size in 86 community-dwelling older adults without ADRDs – after adjusting for age, sex, education, global health, and total intracranial volume. Results: The mean age was 75.20 years, mean years of education 15.66, and 53% identified as female. On average, participants reported 5.26 high-contact social relationships, and 22.98 individuals in their overall social network. We identified gray matter volume covariance networks associated with both high-contact social relationships and overall social network size. We also found that greater expression of these networks were associated with better episodic memory, but not with processing speed or executive function. Shared nodes in these networks included medial, lateral and orbital prefrontal cortex, hippocampal, precuneus, insular and cingulate regions. A more extended network of brain regions was associated with high-contact social relationships than overall social network size – also including parahippocampal, amygdala, and entorhinal cortex regions. Conclusions: Social networks in older adults is associated with distributed gray matter volume networks that are closely linked with episodic memory performance and are composed of regions previously linked to both normal and ADRD-related aging. High-contact social relationships may also be a more sensitive measure of age-related and ADRD-related changes in the brain than overall social network size.