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P4‐088: EVOLUTION OF THE AWARENESS OF COGNITIVE DECLINE INDEX OVER 24 MONTHS IN PRECLINICAL ALZHEIMER'S DISEASE IS ASSOCIATED TO BASELINE BRAIN AMYLOID LOAD
Author(s) -
Sambati Luisa,
Houot Marion,
Cacciamani Federica,
Habert Marie-Odile,
Dubois Bruno,
Epelbaum Stéphane
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2491
Subject(s) - medicine , cognitive decline , neuropsychology , cohort , standardized uptake value , cognition , disease , dementia , gerontology , positron emission tomography , nuclear medicine , psychiatry
bed-ridden by the spring of 2016with almost permanent drowsiness and still retains this state by the submission date of this abstract. Conclusions: To our knowledge, excluding one adolescent boy whose disease onset was at 13 years of age, this case is the youngest so far reported. Although extremely rare, this diagnosis must not be overlooked in a patient with chronic insomnia and subacute progressive cerebellar syndrome, when more likely and most often treatable causes like autoimmune encephalitides, such as Morvan’s syndrome or NMDAR encephalitis are excluded after a meticulous work-up.