Premium
P4‐073: IN ABSENCE OF DEMENTIA, COGNITIVE PERFORMANCE DOES NOT RELATE TO THE BIOMARKER OF LEUKOCYTE TELOMERE LENGTH: AN EXAMINATION OF LONG LIFE FAMILY STUDY PARTICIPANTS
Author(s) -
Ashrafi Adiba,
Cosentino Stephanie,
Kang Min Suk,
Lee Joseph H.,
Schupf Nicole,
Andersen Stacy L.,
Christensen Kaare,
Province Michael A.,
Thyagarajan Bharat,
Zmuda Joseph M.,
Honig Lawrence S.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2476
Subject(s) - dementia , telomere , gee , offspring , cohort , medicine , biomarker , cognition , population , cognitive decline , demography , generalized estimating equation , gerontology , psychology , disease , genetics , biology , psychiatry , dna , pregnancy , statistics , mathematics , environmental health , sociology
BACE1 and NFL (a marker of axonal damage) sampling. Participants were stratified into Ab-PET+ and Ab-PET-. We investigated differences in BACE1 concentrations according to Ab-PET status, APOE genotype, and sex. We analysed associations between BACE1 and Ab-PET SUVR and between BACE1 and NFL concentrations. Results: No association was found between BACE1 and APOE genotype. A trend towards a positive association was found whenperforming regressionbetweenglobalSUVR(outcomevariable) and BACE1 concentrations. NFL and BACE1 correlated, both in the whole cohort and in the Ab-PET+ subgroup (r1⁄40.149, p1⁄40.009 and r1⁄40.331, p1⁄40.002 respectively). The univariate linear regression models showed that women demonstrate significantly higher plasma BACE1 concentrations compared to men even after controlling for age (adjusted R1⁄40.067, p<0.001). In the female group, there was a significant difference of Ab-PET status (higher concentrations in the Ab-PET+ group (adjusted R1⁄40.017, p1⁄40.039), positive association betweenBACE1andglobalmeanSUVR(r1⁄40.167, p1⁄40.021).Conclusions:The results demonstrate sex-related increases of plasma BACE1 concentrations in women compared to men. In women, BACE1 was significantly different in AbPET status (increased in the AbPET+ group). BACE1 was associated with NFL, a surrogate marker of axonal damage in AbPET+ rather than in AbPET-, indicating that BACE1 may impact dendritic spine dynamics.