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P4‐072: INCREASED PLASMA BACE1 CONCENTRATIONS IN WOMEN WITH SUBJECTIVE MEMORY COMPLAINTS: CORRELATION WITH PLASMA NFL
Author(s) -
Lista Simone,
Vergallo Andrea,
Megret Lucile,
Bun René Sosata,
Vanmechelen Eugeen,
De Vos Ann,
Lamari Foudil,
Genthon Remy,
Cavedo Enrica,
Habert Marie-Odile,
Neri Christian,
Dubois Bruno,
Hampel Harald
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2475
Subject(s) - biomarker , cohort , logistic regression , neurite , medicine , apolipoprotein e , correlation , endocrinology , oncology , chemistry , gastroenterology , psychology , disease , biochemistry , mathematics , in vitro , geometry
analysis, logistic regression analysis, and then a Receiver Operation Characteristic curve. Association analysis between cfssDNA and AD analytes will be performed. Results: Pair T test combined analysis demonstrated that cfssDNA concentration in AD samples is significantly lower than non-demented control samples. (2 tail pvalue 0.0007). Logistic regression analysis shows that cfssDNA concentration can predict AD status and the power of prediction increases when age included in the model (p-value<0.0001). Finally, ROC curve has a score of 0.82 in all three datasets. Association analysis between cfssDNA and analytes for AD will be reported at the conference. Conclusions: cfssDNA concentration in CSF is significantly lower in AD cases than non-demented controls. Due to this finding cfss DNA can be added as a possible biomarker to monitor the development of AD.