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P4‐049: IDENTIFICATION OF CELL‐SPECIFIC DIFFERENTIALLY EXPRESSED GENES IN ALZHEIMER'S DISEASE
Author(s) -
Wang Xue,
Allen Mariet,
Carrasquillo Minerva M.,
Burgess Jeremy D.,
Li Shaoyu,
Asmann Yan W.,
Ertekin-Taner Nilufer
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2451
Subject(s) - biology , cell type , cell , gene , transcriptome , gene expression , population , dorsolateral prefrontal cortex , microglia , computational biology , genetics , neuroscience , prefrontal cortex , immunology , medicine , inflammation , cognition , environmental health
in maintaining open chromatin (Wan et al. 2013), and mitochondrial protein Surf1, previously linked to brain resilience after excitotoxic insult (Lin et al., 2013), as specific targets that may be leveraged to drive transcriptional networks to promote resilience. Conclusions:Our work using the AD-BXD panel demonstrates that by incorporating genetic diversity, we can improve the translational relevance of mouse models. Here we take advantage of access to brain tissue at pre-symptomatic time points and identify key gene expression signatures predictive of cognitive status late in disease. Overall, our results highlight potential mechanisms and candidate genes that may be targeted in at-risk individuals to promote resilience. Ongoing work in the lab will further investigate identified hub genes and seek to evaluate their utility as therapeutic targets.