P4‐034: HIGH‐DIMENSIONAL VARYING COEFFICIENT MODELS FOR ALZHEIMER'S DISEASE DIAGNOSIS WITH LONGITUDINAL AND HETEROGENEOUS STRUCTURAL MR IMAGES

Subcortical ischaemic vascular lesion is closely related to small vessel disease and pathologically manifest as lipohylinosis and arteriosclerosis. As one expects and due the heterogeneous pathophysiological causes the clinical course and presentation differs between them. Methods:We collected baseline global cognitive score with multiple cognitive screening tests including ADAS-cog, MMSE and MoCA from patients diagnosed with mild cognitive impairment-VCI (n1⁄434). We performed neuropsychological testing focusing on executive function with paper stroop test and Trails A&B. We also Assessed mobility performance with Time up and go test (TUG) and Gait speed. All the subjects had a brain MRI and the white matter lesions was visually rated by fazekas’ scale and the volume was quantified for the total, deep and periventricular white matter lesion with a semi-automated technique. Results:We found a significant association between the deep but not the periventricular white matter lesion volumewith measures of executive function. Deep White matter lesion was significantly associated with blood pressure. Neither the Deep nor the periventricualr white matter lesion volume was associated with measures of global cognition, gait speed or pulse wave velocity. Conclusions: periventricular white matter lesion volume was not associated with global cognitive function, executive function or Gait speed.