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P4‐032: UNTANGLING ALZHEIMER'S DISEASE HALLMARKS IN SENSORY SYSTEMS OF RODENT MODELS
Author(s) -
Rabl Roland,
Aguilo Meritxell,
Loeffler Tina,
Neddens Joerg,
Lopez-Pardo Ainara,
Niederkofler Vera,
Flunkert Stefanie,
Hutter-Paier Birgit
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2434
Subject(s) - neuropathology , neuroscience , olfactory bulb , retina , pathology , olfactory system , dementia , neuroinflammation , piriform cortex , sensory system , biology , disease , medicine , psychology , central nervous system
amyloid beta(Ab) and protecting nerve cells. Furthermore, 6MSITC has been reported to be absorbed a high rate in the body, which is considered to be about from 40 to 60%. Other isothiocyanate, as an analog of 6-MSITC, has been reported to permeate the brain blad barrier. Therefore, 6-MSITC can be considered as an effective compound for brain function. Methods: The doubleblinded clinical study was conducted using 6-MSITC (25 placebo, 25 subjects, 8 weeks ingestion), and the rat pheochromocytoma cell line, PC12, were used to study the synergistic effects for the neurite outgrowth, dopamine secretion and Ab toxicity by 6-MSITC, DHA, curcumin, isorhamnetin. Results:Significant results were obtained by the clinical test. Furthermore, we found that 6-MSITC reduced the toxicity from Ab, increased secretion of dopamine on nerve cells. 6-MSITC also has synergistic effects of DHA, curcumin, and ginkgo biloba compound, which are considered to be good compounds for improvement of brain function. Conclusions: Thus, 6-MSITC may be used a compound to prevent Alzheimer’s disease.