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P4‐031: NOVEL MODELS OF LATE‐ONSET ALZHEIMER'S DISEASE BASED ON GWAS
Author(s) -
Sasner Michael,
Williams Harriet M.,
Oblak Adrian L.,
O'Rourke Rita,
Preuss Christoph,
Saykin Andrew J.,
Sukoff Rizzo Stacey J.,
Ananda Guruprasad,
Philip Vivek,
Carter Gregory W.,
Lamb Bruce T.,
Howell Gareth
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2433
Subject(s) - trem2 , genome wide association study , psen1 , disease , computational biology , phenotype , biology , genetic model , allele , apolipoprotein e , bioinformatics , medicine , genetics , single nucleotide polymorphism , alzheimer's disease , gene , presenilin , genotype , receptor , myeloid cells
amyloid beta(Ab) and protecting nerve cells. Furthermore, 6MSITC has been reported to be absorbed a high rate in the body, which is considered to be about from 40 to 60%. Other isothiocyanate, as an analog of 6-MSITC, has been reported to permeate the brain blad barrier. Therefore, 6-MSITC can be considered as an effective compound for brain function. Methods: The doubleblinded clinical study was conducted using 6-MSITC (25 placebo, 25 subjects, 8 weeks ingestion), and the rat pheochromocytoma cell line, PC12, were used to study the synergistic effects for the neurite outgrowth, dopamine secretion and Ab toxicity by 6-MSITC, DHA, curcumin, isorhamnetin. Results:Significant results were obtained by the clinical test. Furthermore, we found that 6-MSITC reduced the toxicity from Ab, increased secretion of dopamine on nerve cells. 6-MSITC also has synergistic effects of DHA, curcumin, and ginkgo biloba compound, which are considered to be good compounds for improvement of brain function. Conclusions: Thus, 6-MSITC may be used a compound to prevent Alzheimer’s disease.