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P4‐007: A COMBINATION OF ESSENTIAL FATTY ACIDS, PANAX GINSENG EXTRACT, AND GREEN TEA CATECHINS SIGNIFICANTLY INCREASES BRAIN ACTIVATION AND FUNCTIONAL CONNECTIVITY DURING AN FMRI TASK IN HEALTHY OLDER ADULTS
Author(s) -
Carmichael Owen T.,
Pillai Sreekrishna R.,
Shankapal Preetham,
McLellan Alex,
Kay Denis G.,
Gold Brian T.,
Keller Jeffrey N.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2409
Subject(s) - effects of sleep deprivation on cognitive performance , placebo , functional magnetic resonance imaging , anterior cingulate cortex , crossover study , cingulate cortex , middle frontal gyrus , psychology , cognition , ginseng , bioavailability , medicine , pharmacology , neuroscience , central nervous system , alternative medicine , pathology
This aMCI stage represents a crucial time window to apply preventive interventions in an attempt to delay cognitive decline. Stress, one of AD’s modifiable risk factors and frequently co-occurring with aMCI, stands out as a key intervention target. The goal of this study was to assess the impacts of two non-pharmacological interventions, mindfulness and psychoeducation, on stress at the psychological and physiological level among aMCI older adults. Methods:Forty-eight aMCI participants were randomized between mindfulness based intervention (MBI) and psychoeducation based intervention (PBI) for 8 weekly sessions. Perceived stress level, cortisol awakening response (CAR) and coping strategies were assessed preand post-intervention. Data regarding mindfulness attitudes and time dedicated to at-home meditative practices were collected only for MBI. Results:The results revealed: 1) a reduction of CAR amongMBI participants who practiced at-homemeditation the most; 2) a decrease of perceived stress level for PBI; 3) an increase in mindfulness attitudes for MBI and; 4) enhanced problem-focused coping strategies for both interventions. Conclusions: In sum, this study supports the potential of MBI and PBI to reduce stress at the physiological and psychological level, respectively, and increase coping strategies in older adults at risk for AD with few therapeutic options.