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O1‐11‐03: EXCESSIVE NAPPING AND INCREASED 12‐YEAR RISK OF DEVELOPING DEMENTIA IN OLDER MEN
Author(s) -
Leng Yue,
Ancoli-Israel Sonia,
Redline Susan,
Barrett-connor Elizabeth,
Stone Katie,
Yaffe Kristine
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2392
Subject(s) - dementia , actigraphy , logistic regression , medicine , depression (economics) , cognition , gerontology , cognitive decline , physical therapy , psychology , psychiatry , insomnia , disease , economics , macroeconomics
95%CI: 1.14, 2.72, p1⁄4 0.02) compared to OSA-/Ab+ subjects. Being OSA+/Abdid not reveal significant differences in time-to-progression from MCI to AD when compared to OSA-/Absubjects (aHR) 1⁄4 1.17, 95% CI: 0.86, 1.48, p 1⁄4 0.07). Conclusions:Among MCI patients, brain amyloid levels may modify the relationship between OSA and AD. Furthermore OSA+ subjects maybe more physiologically susceptible to Ab load at certain threshold levels.