F1‐04‐03: EFFECTS OF AGE AND TAU MEASURED IN CSF ON MNEMONIC DISCRIMINATION OF OBJECTS AND SCENES IN MEDIAL TEMPORAL LOBE PATHWAYS

responses in the precuneus and this association was independent of CSF t-tau levels, DELCODE site, age and gender. A mediation analysis showed that precuneus volume did not mediate the relationship between Aß-42 levels and novelty responses Conclusions: These results indicate that CSF indices of tau and amyloid pathology are associated with independent and anatomically specific functional reductions in memory processing. The anatomical specificity is compatible with the predilection areas of tauand amyloid pathology as known from molecular imaging studies and post mortem histology. These associations remain robust after considering the structural integrity of the same brain region and hence indicate that both pathologies cause synaptic dysfunction independent of neurodegeneration. The independent functional impact of tauand amyloid pathology shows their additive interaction is not necessary to cause neuronal dysfunction.