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IC‐P‐225: PARTIAL VOLUME CORRECTION USING EITHER PMOD ® OR CAPAIBL ® DOES LITTLE TO IMPROVE 18 F‐AV1451 PET QUANTIFICATION
Author(s) -
Williams Scott,
Bourgeat Pierrick,
Villemagne Victor L.,
Fripp Jurgen,
Salvado Olivier,
Rowe Christopher C.,
Dore Vincent
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2292
Subject(s) - nuclear medicine , partial volume , grey matter , atrophy , neocortex , medicine , psychology , magnetic resonance imaging , neuroscience , white matter , radiology
ERC and the Early NFT cluster of the hippocampus compared to the Off-Target cluster (p<0.001; Figure 2). Conclusions: Using data-driven methods, we were able to enhance the associations expected from pathology studies between hippocampal AV1451 signal and other pathological and cognitive markers. These findings partially resolve discrepancies between previous PET and pathology studies and provide a template for future AV1451 studies.