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IC‐P‐224: HETEROGENEOUS TAU‐PET SIGNAL IN THE HIPPOCAMPUS HELPS RESOLVE DISCREPANCIES BETWEEN IMAGING AND PATHOLOGY
Author(s) -
Vogel Jacob W.,
Ossenkoppele Rik,
Kiar Gregory,
Medina Yasser Iturria,
Baker Suzanne L.,
Hansson Oskar,
Evans Alan C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2291
Subject(s) - hippocampus , entorhinal cortex , hippocampal formation , neuroscience , positron emission tomography , neuroimaging , alzheimer's disease , voxel , psychology , dementia , pittsburgh compound b , medicine , pathology , disease , cognitive impairment , cognition , radiology
more likely to be Ab positive (top left), had worse episodic memory scores (top right) and were more frequently diagnosed with AD dementia (bottom left). These associations were enhanced when only looking in hippocampal voxels within the early NFT cluster (turquoise), and were diminished when using voxels in the off-target cluster (purple). The Early NFT cluseter demonstrated greater anatomical connections with the entorhinal cortex as measured using diffusion tractography imaging (bottom right). Poster Presentations: Saturday, July 21, 2018 P182