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IC‐P‐215: TAU ACCUMULATION IN RHINAL CORTEX IS ASSOCIATED WITH MEMORY PERFORMANCE IN NON‐DEMENTED YOUNG ADULTS WITH AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE
Author(s) -
Sanchez Justin S.,
Sperling Reisa A.,
Lopera Francisco,
Augustinack Jean,
Becker Alex,
Jacobs Heidi IL.,
Jin David,
Katz Samantha,
Luner Evelyn,
Moody Kirsten,
Price Julie C.,
Guzman-Velez Edmarie,
Baena Ana,
Pardilla-Delgado Enmanuelle,
Chen Kewei,
Reiman Eric M.,
Johnson Keith A.,
Quiroz Yakeel T.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2282
Subject(s) - entorhinal cortex , psen1 , presenilin , cortex (anatomy) , psychology , pathology , dementia , alzheimer's disease , neuroscience , medicine , hippocampus , disease
and cognition in a cohort of older adults with normal cognition (CN), subjective cognitive decline (SCD), and mild cognitive impairment (MCI).Methods:23 CN, 17 SCD, and 9MCI underwent [F]Flortaucipir PET scans, cognitive testing, and the short-form of the MIND diet inventory [1]. [F]Flortaucipir PET scans were processed using standard techniques and intensity-normalized to the cerebellar crus. Regional mean [F]Flortaucipir SUVRwas extracted from target regions, including the medial temporal lobe (MTL, includes entorhinal cortex, fusiform, and parahippocampal gyri) and the lateral temporal lobe (includes inferior, middle, and superior temporal gyri). High red meat intake was defined as >3 servings of red meat per week [1]. The relationship between high red meat intake, diagnosis, and cognition and [F]Flortaucipir SUVR was evaluated using a two-way ANOVA. Education was included as a covariate in the cognitive analyses. No other covariates (age, sex, history of cardiovascular disease) were significantly associated with any of the measures or significant within the statistical model. Results: High red meat intake was associated with increased [F]Flortaucipir SUVR in the MTL (Figure 1A; main effect for red meat intake: p1⁄40.014) and LTL (Figure 1B, p1⁄40.025). Further, high red meat intake was associated with poorer performance on the Rey AVLT Delayed Recall (Figure 2A, p1⁄40.037) and at a trend level on other cognitive tests, including the Digit Symbol Substitution Test (Figure 2B, p1⁄40.091) and Forward Digit Span (Figure 2C, p1⁄40.098). There were no interactions between red meat intake and diagnosis. Conclusions:These findings are preliminary due to the small sample size but our findings suggest a link between consumption of red meat (>3 servings per week) and increased cerebral tau and poorer memory. These effects were not mediated by history of cardiovascular disease or diagnosis, suggesting an independent link between red meat intake and tau pathology. Future studies in larger samples are needed to further investigate this association. Reference: [1] Morris et al. (2015) Alzheimer’s & Dementia.