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IC‐P‐210: COMPARISON OF IN VIVO [F‐18]AV‐1451 OFF‐TARGET RETENTION IN AFRICAN‐AMERICANS AND CAUCASIANS
Author(s) -
Minhas Davneet S.,
Laymon Charles M.,
Tudorascu Dana L.,
Lopresti Brian J.,
Aizenstein Howard J.,
Lopez Oscar L.,
Ikonomovic Milos D.,
Reis Steven E.,
Mathis Chester,
Klunk William E.,
Cohen Annie
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2277
Subject(s) - substantia nigra , medicine , neuromelanin , nuclear medicine , choroid plexus , central nervous system , dopamine , dopaminergic
differences between Ab-positive and Ab-negative subjects using t-tests. In the identified regions, we then assessed whether tau SUVR was related to CSF p-tau and cognition using linear regression models. Results: Only three individuals were classified as tau-positive (EC SUVR 1.3), while 15 were Ab-positive (SUVR 1.4; Fig.1a-b). Despite low tau signal, Ab-positive individuals had higher AV1451 SUVRs than Ab-negative ones in the EC, amygdala, inferior temporal, lateral occipital, fusiform and parahippocampal gyri (all p 0.03; Fig.2a-c). AV1451 SUVRs in all aforementioned regions (except inferior temporal and fusiform gyri) were positively associated with CSF p-tau (p<0.05; Fig.3a). Finally, higher EC, amygdala, inferior temporal and lateral occipital AV1451 SUVRs were associated with lower delayed memory, language, and total RBANS index scores (p<0.05; Fig.3b). There was no Ab status * AV1451-SUVR interaction on CSF p-tau or cognition. When the three tau-positive subjects were removed from the analyses, results remained similar. Conclusions: These findings indicate that, even in latemiddle-aged adults with relatively low AV1451 SUVRs, AV1451 binding in AD signature regions is significantly increased among Ab-positive individuals. Higher tau binding is also associated with higher CSF p-tau and lower cognition. Overall, this suggests that early tau-PET changes in AD-typical regions are clinically meaningful.