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IC‐P‐202: AV1451 TAU TRACER UPTAKE CORRELATES WITH HIPPOCAMPAL CA1 SUBFIELD ATROPHY IN AMYLOID‐NEGATIVE INDIVIDUALS
Author(s) -
Das Sandhitsu R.,
Ittyerah Ranjit,
Wisse Laura,
Xie Long,
Yushkevich Paul A.,
Wolk David A.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2269
Subject(s) - subiculum , entorhinal cortex , perirhinal cortex , hippocampal formation , parahippocampal gyrus , tauopathy , temporal lobe , atrophy , dentate gyrus , neuroscience , hippocampus , psychology , temporal cortex , pathology , medicine , neurodegeneration , disease , epilepsy
cMFG relative to svPPA [F(1,11)1⁄412.47, p1⁄4.005]. Amongst the svPPA and nfvPPA patients, auditory verbal working memory impairment was predicted by Flortaucipir signal in the MTG [r(10)1⁄4-.604, p1⁄4.032], whereas verbal fluency impairment was predicted by Flortaucipir signal in the IFG [r(7)1⁄4-.702, p1⁄4.039]. All results remained similar when the analysis was repeated without partial volume correction and in the right hemisphere. Conclusions:Our results suggest that Flortaucipir imaging is useful for distinguishing between PPA patients with and without Alzheimer’s pathology; and that Flortaucipir signal in PPA patients without Alzheimer’s pathology is behaviorally relevant.