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IC‐P‐201: FLORTAUCIPIR IMAGING IN PRIMARY PROGRESSIVE APHASIA PREDICTS VARIABILITY IN LANGUAGE IMPAIRMENT
Author(s) -
Collins Jessica A.,
Quimby Megan,
Makaretz Sara J.,
McGinnis Scott M.,
Dickerson Brad C.
Publication year - 2018
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2018.06.2268
Subject(s) - primary progressive aphasia , medicine , inferior frontal gyrus , audiology , aphasia , middle temporal gyrus , neuroimaging , neuroscience , pathology , psychology , functional magnetic resonance imaging , radiology , frontotemporal dementia , psychiatry , disease , dementia
Background:[F]MK-6240 is a promising PET radioligand for in vivo detection of neurofibrillary tau tangles in Alzheimer’s disease (AD). Characterization of target and off-target binding features is required to improve the interpretation of the PET signal as it relates to neurofibrillary tau. This work probes spatial and kinetic features of [F]MK-6240 binding in target and off-target regions to determine the optimal imaging parameters in humans ranging from young controls to AD. Methods: Fifty-one participants (3 young controls, 33 older controls, 6 longitudinal cognitive declining, 2 MCI, 7 probable AD) underwent [F]MK-6240 PET and T1-weighted MRI scans. [C]PiB PET scans were acquired to assess amyloid burden (young controls assumed amyloid negative). [F]MK-6240 scans were acquired up to 120 minutes following 10 mCi bolus injection. Parametric SUVR images (70-90 min) were generated and warped to MNI space (inferior cerebellar GM reference region). Mean SUVR images were generated across groups to identify potential off-target binding regions and guide ROI delineation. [F]MK-6240 time-activ-